# CPT 81225: CYP2C19 gene analysis

Medicare CPT 81225 pays $291.36 under the 2026 Q4 Medicare Clinical Laboratory Fee Schedule, the same national rate in every state.

Web page: https://www.med-reveal.com/rates/81225-cpt-fee-schedule
Section: Laboratory and Pathology

## Medicare rates

| | Amount |
| --- | --- |
| National non-facility | $291.36 |
| National facility | $291.36 |
| Release | 2026 Q4 (effective 2026-10-01) |

## Related codes

- 81162: BRCA1, BRCA2 gene analysis, full sequence and duplication/deletion — https://www.med-reveal.com/rates/81162-cpt-fee-schedule
- 81170: ABL1 gene analysis — https://www.med-reveal.com/rates/81170-cpt-fee-schedule
- 81201: APC gene analysis — https://www.med-reveal.com/rates/81201-cpt-fee-schedule
- 81210: BRAF gene analysis — https://www.med-reveal.com/rates/81210-cpt-fee-schedule
- 81215: BRCA1 gene analysis, known familial variant — https://www.med-reveal.com/rates/81215-cpt-fee-schedule
- 81226: CYP2D6 gene analysis — https://www.med-reveal.com/rates/81226-cpt-fee-schedule
- 81240: F2 gene analysis (prothrombin) — https://www.med-reveal.com/rates/81240-cpt-fee-schedule
- 81241: F5 gene analysis (Factor V Leiden) — https://www.med-reveal.com/rates/81241-cpt-fee-schedule

Commercial negotiated rates for 81225 by payer and state: https://www.med-reveal.com/solutions/rate-benchmarking

## Sources

- CMS Medicare fee schedules (2026 Q4): https://www.cms.gov/medicare/payment/fee-schedules