# CPT 88121: Cytopathology, in situ hybridization, urinary tract specimen, manual

Medicare CPT 88121 pays $393.80 in a non-facility setting and $393.80 in a facility setting under the 2026 Medicare Physician Fee Schedule, before geographic adjustment. After geographic adjustment, state amounts run from $342.43 in Arkansas to $460.29 in California, a 34% spread.

Web page: https://www.med-reveal.com/rates/88121-cpt-fee-schedule
Section: Laboratory and Pathology

## Medicare rates

| | Amount |
| --- | --- |
| National non-facility | $393.80 |
| National facility | $393.80 |
| Conversion factor | 33.4009 |
| Release | 2026 Q4 (effective 2026-10-01) |

## By state

| State | Non-facility | Facility |
| --- | --- | --- |
| California | $460.29 | $460.29 |
| District of Columbia | $459.75 | $459.75 |
| Washington | $444.91 | $444.91 |
| Hawaii | $442.52 | $442.52 |
| New Jersey | $440.92 | $440.92 |
| Massachusetts | $438.95 | $438.95 |
| New York | $437.41 | $437.41 |
| Alaska | $432.95 | $432.95 |
| Connecticut | $422.43 | $422.43 |
| Colorado | $416.92 | $416.92 |
| Oregon | $412.94 | $412.94 |
| Maryland | $409.62 | $409.62 |
| New Hampshire | $408.38 | $408.38 |
| Rhode Island | $406.15 | $406.15 |
| Minnesota | $403.29 | $403.29 |
| Puerto Rico | $397.73 | $397.73 |
| Virgin Islands | $397.73 | $397.73 |
| Florida | $396.26 | $396.26 |
| Nevada | $393.93 | $393.93 |
| Montana | $393.79 | $393.79 |
| Wyoming | $393.45 | $393.45 |
| North Dakota | $393.00 | $393.00 |
| South Dakota | $392.91 | $392.91 |
| Vermont | $389.54 | $389.54 |
| Delaware | $389.51 | $389.51 |
| Texas | $388.31 | $388.31 |
| Virginia | $387.29 | $387.29 |
| Pennsylvania | $386.81 | $386.81 |
| Illinois | $382.99 | $382.99 |
| Arizona | $382.45 | $382.45 |
| Wisconsin | $377.76 | $377.76 |
| Georgia | $377.56 | $377.56 |
| Maine | $377.29 | $377.29 |
| Michigan | $372.40 | $372.40 |
| Utah | $372.08 | $372.08 |
| North Carolina | $369.21 | $369.21 |
| Indiana | $366.85 | $366.85 |
| South Carolina | $366.26 | $366.26 |
| Nebraska | $365.27 | $365.27 |
| Idaho | $364.31 | $364.31 |
| New Mexico | $364.21 | $364.21 |
| Missouri | $364.16 | $364.16 |
| Louisiana | $362.56 | $362.56 |
| Ohio | $362.51 | $362.51 |
| Iowa | $362.41 | $362.41 |
| Tennessee | $360.44 | $360.44 |
| Kansas | $358.60 | $358.60 |
| Oklahoma | $355.01 | $355.01 |
| Kentucky | $353.75 | $353.75 |
| Alabama | $348.25 | $348.25 |
| West Virginia | $347.25 | $347.25 |
| Mississippi | $343.45 | $343.45 |
| Arkansas | $342.43 | $342.43 |

## Related codes

- 88104: Cytopathology, fluids/washings, smears with interpretation — https://www.med-reveal.com/rates/88104-cpt-fee-schedule
- 88106: Cytopathology, filter method, smears with interpretation — https://www.med-reveal.com/rates/88106-cpt-fee-schedule
- 88108: Cytopathology, concentration technique, smears — https://www.med-reveal.com/rates/88108-cpt-fee-schedule
- 88112: Cytopathology, selective cellular enhancement technique — https://www.med-reveal.com/rates/88112-cpt-fee-schedule
- 88120: Cytopathology, in situ hybridization, urinary tract specimen, computer-assisted — https://www.med-reveal.com/rates/88120-cpt-fee-schedule
- 88125: Cytopathology, forensic — https://www.med-reveal.com/rates/88125-cpt-fee-schedule
- 88141: Cytopathology, cervical/vaginal, requiring interpretation by physician — https://www.med-reveal.com/rates/88141-cpt-fee-schedule
- 88142: Cytopathology, cervical/vaginal, thin layer preparation, manual screening — https://www.med-reveal.com/rates/88142-cpt-fee-schedule

Commercial negotiated rates for 88121 by payer and state: https://www.med-reveal.com/solutions/rate-benchmarking

## Sources

- CMS Medicare fee schedules (2026 Q4): https://www.cms.gov/medicare/payment/fee-schedules