# CPT 88377: In situ hybridization, multiplex probe

Medicare CPT 88377 pays $384.11 in a non-facility setting and $384.11 in a facility setting under the 2026 Medicare Physician Fee Schedule, before geographic adjustment. After geographic adjustment, state amounts run from $335.94 in Arkansas to $446.90 in California, a 33% spread.

Web page: https://www.med-reveal.com/rates/88377-cpt-fee-schedule
Section: Laboratory and Pathology

## Medicare rates

| | Amount |
| --- | --- |
| National non-facility | $384.11 |
| National facility | $384.11 |
| Conversion factor | 33.4009 |
| Release | 2026 Q4 (effective 2026-10-01) |

## By state

| State | Non-facility | Facility |
| --- | --- | --- |
| California | $446.90 | $446.90 |
| District of Columbia | $446.72 | $446.72 |
| Washington | $432.46 | $432.46 |
| Hawaii | $429.72 | $429.72 |
| New Jersey | $429.04 | $429.04 |
| Alaska | $428.30 | $428.30 |
| Massachusetts | $426.83 | $426.83 |
| New York | $425.72 | $425.72 |
| Connecticut | $411.26 | $411.26 |
| Colorado | $405.94 | $405.94 |
| Oregon | $402.14 | $402.14 |
| Maryland | $399.13 | $399.13 |
| New Hampshire | $397.76 | $397.76 |
| Rhode Island | $395.96 | $395.96 |
| Minnesota | $392.94 | $392.94 |
| Puerto Rico | $387.80 | $387.80 |
| Virgin Islands | $387.80 | $387.80 |
| Florida | $386.50 | $386.50 |
| Nevada | $384.22 | $384.22 |
| Montana | $384.11 | $384.11 |
| Wyoming | $383.76 | $383.76 |
| North Dakota | $383.32 | $383.32 |
| South Dakota | $383.22 | $383.22 |
| Delaware | $380.16 | $380.16 |
| Vermont | $380.08 | $380.08 |
| Texas | $379.04 | $379.04 |
| Virginia | $377.99 | $377.99 |
| Pennsylvania | $377.71 | $377.71 |
| Illinois | $374.11 | $374.11 |
| Arizona | $373.47 | $373.47 |
| Wisconsin | $369.03 | $369.03 |
| Georgia | $368.94 | $368.94 |
| Maine | $368.61 | $368.61 |
| Michigan | $364.10 | $364.10 |
| Utah | $363.75 | $363.75 |
| North Carolina | $361.05 | $361.05 |
| Indiana | $358.82 | $358.82 |
| South Carolina | $358.30 | $358.30 |
| Nebraska | $357.33 | $357.33 |
| Idaho | $356.45 | $356.45 |
| New Mexico | $356.41 | $356.41 |
| Missouri | $356.34 | $356.34 |
| Louisiana | $354.86 | $354.86 |
| Ohio | $354.80 | $354.80 |
| Iowa | $354.66 | $354.66 |
| Tennessee | $352.82 | $352.82 |
| Kansas | $351.09 | $351.09 |
| Oklahoma | $347.75 | $347.75 |
| Kentucky | $346.59 | $346.59 |
| Alabama | $341.40 | $341.40 |
| West Virginia | $340.54 | $340.54 |
| Mississippi | $336.92 | $336.92 |
| Arkansas | $335.94 | $335.94 |

## Related codes

- 88300: Level I surgical pathology, gross examination only — https://www.med-reveal.com/rates/88300-cpt-fee-schedule
- 88302: Level II surgical pathology, gross and microscopic examination — https://www.med-reveal.com/rates/88302-cpt-fee-schedule
- 88304: Level III surgical pathology, gross and microscopic examination — https://www.med-reveal.com/rates/88304-cpt-fee-schedule
- 88305: Level IV surgical pathology, gross and microscopic examination — https://www.med-reveal.com/rates/88305-cpt-fee-schedule
- 88307: Level V surgical pathology, gross and microscopic examination — https://www.med-reveal.com/rates/88307-cpt-fee-schedule
- 88309: Level VI surgical pathology, gross and microscopic examination — https://www.med-reveal.com/rates/88309-cpt-fee-schedule
- 88311: Decalcification procedure — https://www.med-reveal.com/rates/88311-cpt-fee-schedule
- 88312: Special stain, group I, microorganisms — https://www.med-reveal.com/rates/88312-cpt-fee-schedule

Commercial negotiated rates for 88377 by payer and state: https://www.med-reveal.com/solutions/rate-benchmarking

## Sources

- CMS Medicare fee schedules (2026 Q4): https://www.cms.gov/medicare/payment/fee-schedules